Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin...
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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RNF213 is the major susceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Characterization of disease-associated mutations has been complicated by the enormous size of RNF213. Here, we present the cryo-EM structure of mouse RNF213. The structure reveals the intric...
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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_75607b9332b1404caeb8b255f07add85
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75607b9332b1404caeb8b255f07add85
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.56185
