Structural basis for SARM1 inhibition and activation under energetic stress
Structural basis for SARM1 inhibition and activation under energetic stress
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present cryo-EM maps of SARM1 at 2.9 and 2.7 Å resolutions. These indicate that SARM1 homo-octamer avoi...
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Full title
Structural basis for SARM1 inhibition and activation under energetic stress
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TN_cdi_doaj_primary_oai_doaj_org_article_757a57e42bd944929c69f7eff4349681
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_757a57e42bd944929c69f7eff4349681
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.62021
