Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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The rs72824905 single-nucleotide polymorphism in the PLCG2 gene, encoding the p.P522R residue change in Phospholipase C gamma 2 (PLCγ2), associates with protection against several dementia subtypes and with increased likelihood of longevity. Cell lines and animal models indicated that p.P522R is a functional hypermorph. We aimed to confirm this in...
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Full title
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
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TN_cdi_doaj_primary_oai_doaj_org_article_7589f9cc1f6f47689830c90d78c8317b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7589f9cc1f6f47689830c90d78c8317b
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-023-00604-9
