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Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through tran...

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through tran...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75bea59380ee4facabb9a13db669ea7a

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

About this item

Full title

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2020-06, Vol.11 (1), p.2717-14, Article 2717

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Somatic inactivating mutations of
ARID1A
, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how
ARID1A
deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with
Arid1a
and/or
Pten
 conditional d...

Alternative Titles

Full title

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_75bea59380ee4facabb9a13db669ea7a

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75bea59380ee4facabb9a13db669ea7a

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-020-16416-0

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