Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynam...
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that neuronal AMPK is essential for lifespan extension from TORC1 inhibition, and that TORC1 suppression...
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Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
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TN_cdi_doaj_primary_oai_doaj_org_article_75f6972b9e4a42e6978e901cc13f3d20
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75f6972b9e4a42e6978e901cc13f3d20
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.49158
