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Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antivi...

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antivi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75fc5e0fffec45b99c4b42c17dc10447

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

About this item

Full title

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-09, Vol.9 (1), p.3679-13, Article 3679

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Although annual influenza epidemics affect around 10% of the global population, current treatment options are limited and development of new antivirals is needed. Here, using quantitative phosphoproteomics, we reveal the unique phosphoproteome dynamics that occur in the host cell within minutes of influenza A virus (IAV) infection. We uncover cellu...

Alternative Titles

Full title

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_75fc5e0fffec45b99c4b42c17dc10447

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_75fc5e0fffec45b99c4b42c17dc10447

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-06119-y

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