Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor...
Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6
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Yuan, Fang , Chen, Xin , Fang, Kai-Heng , Wang, Yuanyuan , Lin, Mingyan , Xu, Shi-Bo , Huo, Hai-Qin , Xu, Min , Ma, Lixiang , Chen, Yuejun , He, Shuijin and Liu, Yan
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Human GABAergic interneurons (GIN) are implicated in normal brain function and in numerous mental disorders. However, the generation of functional human GIN subtypes from human pluripotent stem cells (hPSCs) has not been established. By expressing LHX6, a transcriptional factor that is critical for GIN development, we induced hPSCs to form GINs, in...
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Full title
Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6
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TN_cdi_doaj_primary_oai_doaj_org_article_76006e8c49c0472ea3a2caf0ff4e71f1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76006e8c49c0472ea3a2caf0ff4e71f1
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.37382
