Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabo...
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism
About this item
Full title
Author / Creator
Baden, Pascale , Perez, Maria Jose , Raji, Hariam , Bertoli, Federico , Kalb, Stefanie , Illescas, María , Spanos, Fokion , Giuliano, Claudio , Calogero, Alessandra Maria , Oldrati, Marvin , Hebestreit, Hannah , Cappelletti, Graziella , Brockmann, Kathrin , Gasser, Thomas , Schapira, Anthony H. V. , Ugalde, Cristina and Deleidi, Michela
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations in
GBA1
, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher’s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employ global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons...
Alternative Titles
Full title
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism
Authors, Artists and Contributors
Author / Creator
Perez, Maria Jose
Raji, Hariam
Bertoli, Federico
Kalb, Stefanie
Illescas, María
Spanos, Fokion
Giuliano, Claudio
Calogero, Alessandra Maria
Oldrati, Marvin
Hebestreit, Hannah
Cappelletti, Graziella
Brockmann, Kathrin
Gasser, Thomas
Schapira, Anthony H. V.
Ugalde, Cristina
Deleidi, Michela
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_761b2e45e4dd4fa280b1024c64572ba2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_761b2e45e4dd4fa280b1024c64572ba2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37454-4
