Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospher...
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
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Author / Creator
Freire, Natália Hogetop , Herlinger, Alice Laschuk , Vanini, Julia , Dalmolin, Matheus , Fernandes, Marcelo A C , Nör, Carolina , Ramaswamy, Vijay , de Farias, Caroline Brunetto , Brunetto, André Tesainer , Brunetto, Algemir Lunardi , Gregianin, Lauro José , Jaeger, Mariane da Cunha , Taylor, Michael D and Roesler, Rafael
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy....
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Full title
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
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TN_cdi_doaj_primary_oai_doaj_org_article_765251605ae94f1da82e4f8d06704004
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_765251605ae94f1da82e4f8d06704004
Other Identifiers
ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells14020072
