TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
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Author / Creator
Zhu, Rongxuan , Gires, Olivier , Zhu, Liqun , Liu, Jun , Li, Junjian , Yang, Hao , Ju, Gaoda , Huang, Jing , Ge, Weiyu , Chen, Yi , Lu, Zhimin and Wang, Hongxia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1, and correlates with therapeutic resistance. Mech...
Alternative Titles
Full title
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_769dc01c63c3489aa39054afc3be9b52
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_769dc01c63c3489aa39054afc3be9b52
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10739-3
