A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency
A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency
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Author / Creator
Gu, Lili , Sun, Yuling , Wu, Ting , Chen, Ge , Tang, Xiaojun , Zhao, Lianfeng , He, Lingfeng , Hu, Zhigang , Sun, Lingyun , Pan, Feiyan , Yin, Zhimin and Guo, Zhigang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, a proinflammatory form of cell death, is critically important in RA; however, the detailed mechanism underlying pyroptosis induction is not yet well understood. Here, we report that DNA polymerase β (Pol β), a key enzyme in base excision repair, plays...
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Full title
A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency
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TN_cdi_doaj_primary_oai_doaj_org_article_76a5e4292f564b48822c71cfc0adf077
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76a5e4292f564b48822c71cfc0adf077
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05047-6
