Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Structural basis of TRPV1 inhibition by SAF312 and cholesterol
About this item
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Author / Creator
Fan, Junping , Ke, Han , Lei, Jing , Wang, Jin , Tominaga, Makoto and Lei, Xiaoguang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive antagonist of TRPV1 and shows promising potential in treating ocular surface pain. However, the precise mechanism by which SAF312 inhibits TRPV1 remains poo...
Alternative Titles
Full title
Structural basis of TRPV1 inhibition by SAF312 and cholesterol
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_76f10ec5075d4ea089d0013dab1fd995
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76f10ec5075d4ea089d0013dab1fd995
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51085-3
