The Pyrazolo[3,4- d ]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Thera...
The Pyrazolo[3,4- d ]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
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Author / Creator
Rango, Enrico , Pastorino, Fabio , Brignole, Chiara , Mancini, Arianna , Poggialini, Federica , Di Maria, Salvatore , Zamperini, Claudio , Iovenitti, Giulia , Fallacara, Anna Lucia , Sabetta, Samantha , Clementi, Letizia , Valoti, Massimo , Schenone, Silvia , Angelucci, Adriano , Ponzoni, Mirco , Dreassi, Elena and Botta, Maurizio
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Si306, a pyrazolo[3,4-
]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, Si306 antitumor activity is associated with sub-optimal aqueous solubility, which...
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Full title
The Pyrazolo[3,4- d ]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_76fcd042be33447e9734d22a84d6e765
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76fcd042be33447e9734d22a84d6e765
Other Identifiers
ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines10030659
