Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor...
Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Spinal motor neurons (MNs) represent a highly vulnerable cellular population, which is affected in fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). In this study, we show that the heterozygous loss of
SYT13
is sufficient to trigger a neurodegenerative phenotype resembling those ob...
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Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_7716fd763a5e4ff6b0567b3fb8f2622d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7716fd763a5e4ff6b0567b3fb8f2622d
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-06957-3
