Targeting CD38 and PD-1 with isatuximab plus cemiplimab in patients with advanced solid malignancies...
Targeting CD38 and PD-1 with isatuximab plus cemiplimab in patients with advanced solid malignancies: results from a phase I/II open-label, multicenter study
About this item
Full title
Author / Creator
Zucali, Paolo Andrea , Lin, Chia-Chi , Carthon, Bradley C , Bauer, Todd M , Tucci, Marcello , Italiano, Antoine , Iacovelli, Roberto , Su, Wu-Chou , Massard, Christophe , Saleh, Mansoor , Daniele, Gennaro , Greystoke, Alastair , Gutierrez, Martin , Pant, Shubham , Shen, Ying-Chun , Perrino, Matteo , Meng, Robin , Abbadessa, Giovanni , Lee, Helen , Dong, Yingwen , Chiron, Marielle , Wang, Rui , Loumagne, Laure , Lépine, Lucie and de Bono, Johann
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundPreclinical data suggest that concurrent treatment of anti-CD38 and antiprogrammed death 1 (PD-1)/programmed death ligand 1 (PD-L1) antibodies substantially reduce primary tumor growth by reversing T-cell exhaustion and thus enhancing anti-PD-1/PD-L1 efficacy.MethodsThis phase I/II study enrolled patients with metastatic castration-resist...
Alternative Titles
Full title
Targeting CD38 and PD-1 with isatuximab plus cemiplimab in patients with advanced solid malignancies: results from a phase I/II open-label, multicenter study
Authors, Artists and Contributors
Author / Creator
Lin, Chia-Chi
Carthon, Bradley C
Bauer, Todd M
Tucci, Marcello
Italiano, Antoine
Iacovelli, Roberto
Su, Wu-Chou
Massard, Christophe
Saleh, Mansoor
Daniele, Gennaro
Greystoke, Alastair
Gutierrez, Martin
Pant, Shubham
Shen, Ying-Chun
Perrino, Matteo
Meng, Robin
Abbadessa, Giovanni
Lee, Helen
Dong, Yingwen
Chiron, Marielle
Wang, Rui
Loumagne, Laure
Lépine, Lucie
de Bono, Johann
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_77a4d7bd1ff24db7bd8825f9ede35742
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_77a4d7bd1ff24db7bd8825f9ede35742
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003697
