Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine i...
Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
About this item
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Author / Creator
Fehlings, M. , Simoni, Y. , Penny, H. L. , Becht, E. , Loh, C. Y. , Gubin, M. M. , Ward, J. P. , Wong, S. C. , Schreiber, R. D. and Newell, E. W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The analysis of neoantigen-specific CD8
+
T cells in tumour-bearing individuals is challenging due to the small pool of tumour antigen-specific T cells. Here we show that mass cytometry with multiplex combinatorial tetramer staining can identify and characterize neoantigen-specific CD8
+
T cells in mice bearing T3 methylcholanthrene-ind...
Alternative Titles
Full title
Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7858136795e54c05b2eaf80fa3fc40f9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7858136795e54c05b2eaf80fa3fc40f9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00627-z
