Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
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Author / Creator
Duffy, Megan F. , Collier, Timothy J. , Patterson, Joseph R. , Kemp, Christopher J. , Luk, Kelvin C. , Tansey, Malú G. , Paumier, Katrina L. , Kanaan, Nicholas M. , Fischer, D. Luke , Polinski, Nicole K. , Barth, Olivia L. , Howe, Jacob W. , Vaikath, Nishant N. , Majbour, Nour K. , El-Agnaf, Omar M. A. and Sortwell, Caryl E.
Publisher
England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Contents
Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models, interpretations of the role of neuroinflammation as a contributor to...
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Full title
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
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TN_cdi_doaj_primary_oai_doaj_org_article_78b82214e6ad41e9bc7e34dc3be1cf71
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_78b82214e6ad41e9bc7e34dc3be1cf71
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-018-1171-z
