Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation o...
Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular protein epitopes are recorded by index flow cytometry and positions in arrayed microwells, and...
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Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity
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TN_cdi_doaj_primary_oai_doaj_org_article_78bb993491fb4b9faed443f446fb2949
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_78bb993491fb4b9faed443f446fb2949
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07115-y
