p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus...
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
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Author / Creator
Che, Hui , Li, Jie , Li, You , Ma, Cheng , Liu, Huan , Qin, Jingyi , Dong, Jianghui , Zhang, Zhen , Xian, Cory J , Miao, Dengshun , Wang, Liping and Ren, Yongxin
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-induced IVDD model, lumbar intervertebral disc height...
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Full title
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
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TN_cdi_doaj_primary_oai_doaj_org_article_792304d9e0ce4744b78497ea7c9d224e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_792304d9e0ce4744b78497ea7c9d224e
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.52570
