Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Insulin-like growth factors (IGFs) have pleiotropic roles in embryonic and postnatal growth and differentiation. Most serum IGFs are bound in a ternary complex with IGF-binding protein 3 (IGFBP3) and acid-labile subunit (ALS), extending the serum half-life of IGFs and regulating their availability. Here, we report cryo-EM structure of the human IGF...
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Full title
Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
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TN_cdi_doaj_primary_oai_doaj_org_article_798ec222fcee4dcbb60c66cd122017f6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_798ec222fcee4dcbb60c66cd122017f6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32214-2
