Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic analysis of wild-type and three IIS mutant
Cae...
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Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
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TN_cdi_doaj_primary_oai_doaj_org_article_79b32e5ef67f4e64b5c54680fd9b724a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_79b32e5ef67f4e64b5c54680fd9b724a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24816-z
