Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)...
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3S,4S)-3-amino-4-fluorocyclopentenecarboxylic acid (5) was a potent inactivator of γ-aminobutyric acid aminotransferase (GABA-AT), proceeding by an enamine mechan...
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Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid
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TN_cdi_doaj_primary_oai_doaj_org_article_79c28d4ffd014d9f9e4db7231f3c0c7f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_79c28d4ffd014d9f9e4db7231f3c0c7f
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules28031133
