USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
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Author / Creator
Ning, Zhen , Guo, Xin , Liu, Xiaolong , Lu, Chang , Wang, Aman , Wang, Xiaolin , Wang, Wen , Chen, Huan , Qin, Wangshu , Liu, Xinyu , Zhou, Lina , Ma, Chi , Du, Jian , Lin, Zhikun , Luo, Haifeng , Otkur, Wuxiyar , Qi, Huan , Chen, Di , Xia, Tian , Liu, Jiwei , Tan, Guang , Xu, Guowang and Piao, Hai-long
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPARγ) through...
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Full title
USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_7a0b38d3c50c4e26bad4fb004f16686a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a0b38d3c50c4e26bad4fb004f16686a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29846-9
