Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissu...
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Using cells adhering to deformable micropillar arrays, we demonstrate that traction force and FAK localization as well as traction force and Y397-FAK phosphorylation are linearly coupled at individual FAs on stiff, but not soft,...
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Full title
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
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TN_cdi_doaj_primary_oai_doaj_org_article_7a26e4779fb9430c9f01584639edaf32
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a26e4779fb9430c9f01584639edaf32
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22602-5
