Structural basis of the activation of type 1 insulin-like growth factor receptor
Structural basis of the activation of type 1 insulin-like growth factor receptor
About this item
Full title
Author / Creator
Li, Jie , Choi, Eunhee , Yu, Hongtao and Bai, Xiao-chen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we report the cryo-EM structure of full-length IGF1R–IGF1 complex in the active state. This structure reveals that only one IGF1 molecule binds the Γ-shaped asymmetric...
Alternative Titles
Full title
Structural basis of the activation of type 1 insulin-like growth factor receptor
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7a376ae3400f4c8b83371371a1d4709a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a376ae3400f4c8b83371371a1d4709a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12564-0
