Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
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Basel: MDPI AG
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English
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Basel: MDPI AG
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TAR DNA-binding protein 43 (TDP-43) is a predominant component of inclusions in the brains and spines of patients with amyotrophic lateral sclerosis (ALS). The progressive accumulation of inclusions leads to proteinopathy in neurons. We have previously shown that Met1(M1)-linked linear ubiquitin, which is specifically generated by the linear ubiqui...
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Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
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TN_cdi_doaj_primary_oai_doaj_org_article_7a78fbdca5394fbeb4bfd039fceecdf1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a78fbdca5394fbeb4bfd039fceecdf1
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells11152398
