P5CS expression study in a new family with ALDH18A1‐associated hereditary spastic paraplegia SPG9
P5CS expression study in a new family with ALDH18A1‐associated hereditary spastic paraplegia SPG9
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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In 2015–2016, we and others reported ALDH18A1 mutations causing dominant (SPG9A) or recessive (SPG9B) spastic paraplegia. In vitro production of the ALDH18A1 product, Δ1‐pyrroline‐5‐carboxylate synthetase (P5CS), appeared necessary for cracking SPG9 disease‐causing mechanisms. We now describe a baculovirus–insect cell system that yields mgs of pure...
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P5CS expression study in a new family with ALDH18A1‐associated hereditary spastic paraplegia SPG9
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TN_cdi_doaj_primary_oai_doaj_org_article_7aa5233fd46146998c984e96445517f0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7aa5233fd46146998c984e96445517f0
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ISSN
2328-9503
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2328-9503
DOI
10.1002/acn3.50821
