Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of K...
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer
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England: BMJ Publishing Group Ltd
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English
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England: BMJ Publishing Group Ltd
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BackgroundStatins preferentially promote tumor-specific apoptosis by depleting isoprenoid such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have not yet been approved for clinical cancer treatment due, in part, to poor understanding of molecular determinants on statin sensitivity. Here, we investigated the potential...
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Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_7aae6edcd1d94399a85da57101e56e96
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7aae6edcd1d94399a85da57101e56e96
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-002474
