A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1
A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during axonal injury. Its activation mechanism is not fully understood. Here, we generate a nanobody, Nb-C6, that specifically recognizes NMN-activa...
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Full title
A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1
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TN_cdi_doaj_primary_oai_doaj_org_article_7ac80b9e728148edbeca55b6a3fc6886
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7ac80b9e728148edbeca55b6a3fc6886
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35581-y
