Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
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Author / Creator
Zhu, Yuyu , Wu, Zhigui , Yan, Wei , Shao, Fenli , Ke, Bowen , Jiang, Xian , Gao, Jian , Guo, Wenjie , Lai, Yuping , Ma, Hongyue , Chen, Dijun , Xu, Qiang and Sun, Yang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Psoriasis is a complex chronic inflammatory skin disease with unclear molecular mechanisms. We found that the Src homology‐2 domain‐containing protein tyrosine phosphatase‐2 (SHP2) was highly expressed in both psoriatic patients and imiquimod (IMQ)‐induced psoriasis‐like mice. Also, the SHP2 allosteric inhibitor SHP099 reduced pro‐inflammatory cyto...
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Full title
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
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TN_cdi_doaj_primary_oai_doaj_org_article_7b0a4376e81f4df1be1193acb086c2c0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b0a4376e81f4df1be1193acb086c2c0
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202114455
