High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a th...
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The
Plasmodium
cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold was previously shown to clear
P. falciparum
in...
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Full title
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
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TN_cdi_doaj_primary_oai_doaj_org_article_7b1853796974419994e20d37569169f5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b1853796974419994e20d37569169f5
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-42801-x
