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Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical...

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b4b1cd3dc58449fa27c12e396d2f994

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

About this item

Full title

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2025-02, Vol.15 (1), p.4726-19

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The paired box 6 (
Pax6
) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands. Homozygous loss of Pax6 resulted in neonatal death in mice, plus loss of eyes and malformation of cerebral cortex. In patients with heterozygous Pax6 mutations, a reduction in thickness of the front...

Alternative Titles

Full title

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7b4b1cd3dc58449fa27c12e396d2f994

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b4b1cd3dc58449fa27c12e396d2f994

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-025-88662-5

How to access this item