Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cofactor Apoc2 results in significantly reduced HSPC expansion during definitive hematopoiesis...
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Full title
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
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TN_cdi_doaj_primary_oai_doaj_org_article_7b8b171e2a974a31aa37f80a6f9e12b7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b8b171e2a974a31aa37f80a6f9e12b7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03775-y
