Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base edi...
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
About this item
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Author / Creator
Webber, Beau R. , Lonetree, Cara-lin , Kluesner, Mitchell G. , Johnson, Matthew J. , Pomeroy, Emily J. , Diers, Miechaleen D. , Lahr, Walker S. , Draper, Garrett M. , Slipek, Nicholas J. , Smeester, Branden A. , Lovendahl, Klaus N. , McElroy, Amber N. , Gordon, Wendy R. , Osborn, Mark J. and Moriarity, Branden S.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with unintended genomic alterations and gen...
Alternative Titles
Full title
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7b8f9319f4d349b9a42406e609bf1cd4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7b8f9319f4d349b9a42406e609bf1cd4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13007-6
