An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of hu...
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
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Author / Creator
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States) , Colli, Maikel L. , Ramos-Rodríguez, Mireia , Nakayasu, Ernesto S. , Alvelos, Maria I. , Lopes, Miguel , Hill, Jessica L. E. , Turatsinze, Jean-Valery , Coomans de Brachène, Alexandra , Russell, Mark A. , Raurell-Vila, Helena , Castela, Angela , Juan-Mateu, Jonàs , Webb-Robertson, Bobbie-Jo M. , Krogvold, Lars , Dahl-Jorgensen, Knut , Marselli, Lorella , Marchetti, Piero , Richardson, Sarah J. , Morgan, Noel G. , Metz, Thomas O. , Pasquali, Lorenzo and Eizirik, Décio L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently characterize human beta cell responses to IFNα by combining ATAC-seq, RNA-seq and proteomics assays. The initial respo...
Alternative Titles
Full title
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Authors, Artists and Contributors
Author / Creator
Colli, Maikel L.
Ramos-Rodríguez, Mireia
Nakayasu, Ernesto S.
Alvelos, Maria I.
Lopes, Miguel
Hill, Jessica L. E.
Turatsinze, Jean-Valery
Coomans de Brachène, Alexandra
Russell, Mark A.
Raurell-Vila, Helena
Castela, Angela
Juan-Mateu, Jonàs
Webb-Robertson, Bobbie-Jo M.
Krogvold, Lars
Dahl-Jorgensen, Knut
Marselli, Lorella
Marchetti, Piero
Richardson, Sarah J.
Morgan, Noel G.
Metz, Thomas O.
Pasquali, Lorenzo
Eizirik, Décio L.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7ba57ffc94954c2897c0cf413d87e02a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7ba57ffc94954c2897c0cf413d87e02a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16327-0
