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A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7bb7eecfd11145148cad35a3854632b4

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

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Publication information

Publisher

United States: Public Library of Science (PLoS)

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Scope and Contents

Contents

Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (S...

Alternative Titles

Full title

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

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Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7bb7eecfd11145148cad35a3854632b4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7bb7eecfd11145148cad35a3854632b4

Other Identifiers

ISSN

1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.0010008

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