ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
About this item
Full title
Author / Creator
Pinho, Andreia V. , Van Bulck, Mathias , Chantrill, Lorraine , Arshi, Mehreen , Sklyarova, Tatyana , Herrmann, David , Vennin, Claire , Gallego-Ortega, David , Mawson, Amanda , Giry-Laterriere, Marc , Magenau, Astrid , Leuckx, Gunther , Baeyens, Luc , Gill, Anthony J. , Phillips, Phoebe , Timpson, Paul , Biankin, Andrew V. , Wu, Jianmin and Rooman, Ilse
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the stroma. Cell cultures of mice with loss of epithe...
Alternative Titles
Full title
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
Authors, Artists and Contributors
Author / Creator
Van Bulck, Mathias
Chantrill, Lorraine
Arshi, Mehreen
Sklyarova, Tatyana
Herrmann, David
Vennin, Claire
Gallego-Ortega, David
Mawson, Amanda
Giry-Laterriere, Marc
Magenau, Astrid
Leuckx, Gunther
Baeyens, Luc
Gill, Anthony J.
Phillips, Phoebe
Timpson, Paul
Biankin, Andrew V.
Wu, Jianmin
Rooman, Ilse
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7bcf752c0ac345e8b916a29cc45a9a4f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7bcf752c0ac345e8b916a29cc45a9a4f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07497-z
