Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential...
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
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Author / Creator
Boras, Britton , Jones, Rhys M. , Anson, Brandon J. , Arenson, Dan , Aschenbrenner, Lisa , Bakowski, Malina A. , Beutler, Nathan , Binder, Joseph , Chen, Emily , Eng, Heather , Hammond, Holly , Hammond, Jennifer , Haupt, Robert E. , Hoffman, Robert , Kadar, Eugene P. , Kania, Rob , Kimoto, Emi , Kirkpatrick, Melanie G. , Lanyon, Lorraine , Lendy, Emma K. , Lillis, Jonathan R. , Logue, James , Luthra, Suman A. , Ma, Chunlong , Mason, Stephen W. , McGrath, Marisa E. , Noell, Stephen , Obach, R. Scott , O’ Brien, Matthew N. , O’Connor, Rebecca , Ogilvie, Kevin , Owen, Dafydd , Pettersson, Martin , Reese, Matthew R. , Rogers, Thomas F. , Rosales, Romel , Rossulek, Michelle I. , Sathish, Jean G. , Shirai, Norimitsu , Steppan, Claire , Ticehurst, Martyn , Updyke, Lawrence W. , Weston, Stuart , Zhu, Yuao , White, Kris M. , García-Sastre, Adolfo , Wang, Jun , Chatterjee, Arnab K. , Mesecar, Andrew D. , Frieman, Matthew B. , Anderson, Annaliesa S. and Allerton, Charlotte
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. PF-00835231, a 3CL protease inhibitor, has exhibited potent in vitro antiviral activity against SARS-CoV-2 as a single agent. Here we report, the desi...
Alternative Titles
Full title
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
Authors, Artists and Contributors
Author / Creator
Jones, Rhys M.
Anson, Brandon J.
Arenson, Dan
Aschenbrenner, Lisa
Bakowski, Malina A.
Beutler, Nathan
Binder, Joseph
Chen, Emily
Eng, Heather
Hammond, Holly
Hammond, Jennifer
Haupt, Robert E.
Hoffman, Robert
Kadar, Eugene P.
Kania, Rob
Kimoto, Emi
Kirkpatrick, Melanie G.
Lanyon, Lorraine
Lendy, Emma K.
Lillis, Jonathan R.
Logue, James
Luthra, Suman A.
Ma, Chunlong
Mason, Stephen W.
McGrath, Marisa E.
Noell, Stephen
Obach, R. Scott
O’ Brien, Matthew N.
O’Connor, Rebecca
Ogilvie, Kevin
Owen, Dafydd
Pettersson, Martin
Reese, Matthew R.
Rogers, Thomas F.
Rosales, Romel
Rossulek, Michelle I.
Sathish, Jean G.
Shirai, Norimitsu
Steppan, Claire
Ticehurst, Martyn
Updyke, Lawrence W.
Weston, Stuart
Zhu, Yuao
White, Kris M.
García-Sastre, Adolfo
Wang, Jun
Chatterjee, Arnab K.
Mesecar, Andrew D.
Frieman, Matthew B.
Anderson, Annaliesa S.
Allerton, Charlotte
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7c0ac56767d64fb5af7714d7f3a62322
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7c0ac56767d64fb5af7714d7f3a62322
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26239-2
