TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance
TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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CD8+ T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet allograft model and CD3 antibody therapy, we showed, by single cell gene profiling, that intragraft CD8+ lymphocytes coexpressing granzyme B and perforin were selectively depleted through the Fas/FasL...
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Full title
TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance
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TN_cdi_doaj_primary_oai_doaj_org_article_7c54863af7d6404db93efed5b465bfb0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7c54863af7d6404db93efed5b465bfb0
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.08133
