IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulate inside the capsid. An arginine ring within the por...
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Full title
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
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TN_cdi_doaj_primary_oai_doaj_org_article_7c6859948eca463995437484988a1476
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7c6859948eca463995437484988a1476
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.35335
