Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumo...
Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (Btk), a key signaling protein controlling the activation of various immune cells, including macroph...
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Full title
Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia
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TN_cdi_doaj_primary_oai_doaj_org_article_7cc2f9884a124007aa14943727f594cd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7cc2f9884a124007aa14943727f594cd
Other Identifiers
ISSN
1076-1551
E-ISSN
1528-3658
DOI
10.1186/s10020-018-0069-7
