Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
About this item
Full title
Author / Creator
Chen, Chuan’ai , Wang, Dekun , Yu, Yangyang , Zhao, Tianyuan , Min, Ningning , Wu, Yan , Kang, Lichun , Zhao, Yong , Du, Lingfang , Zhang, Mianzhi , Gong, Junbo , Zhang, Zhujun , Zhang, Yuying , Mi, Xue , Yue, Shijing and Tan, Xiaoyue
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia-reperfusion injury (IRI) of renal arteries or folic acid in
lgmn
WT
and
lgmn
KO
mice. We assessed serum creatinine, blood urea nitrogen, histological indexes...
Alternative Titles
Full title
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7cf04265bb20474eaa85caa79f06ec9f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7cf04265bb20474eaa85caa79f06ec9f
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-03362-4
