A substrate binding model for the KEOPS tRNA modifying complex
A substrate binding model for the KEOPS tRNA modifying complex
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Author / Creator
Beenstock, Jonah , Ona, Samara Mishelle , Porat, Jennifer , Orlicky, Stephen , Wan, Leo C. K. , Ceccarelli, Derek F. , Maisonneuve, Pierre , Szilard, Rachel K. , Yin, Zhe , Setiaputra, Dheva , Mao, Daniel Y. L. , Khan, Morgan , Raval, Shaunak , Schriemer, David C. , Bayfield, Mark A. , Durocher, Daniel and Sicheri, Frank
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms examined. In humans, pathogenic mutations in KEOPS genes lead to Galloway–Mowat syndrome, an autosomal-recessive disease causing childhood lethality. Kae1 catalyzes t...
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Full title
A substrate binding model for the KEOPS tRNA modifying complex
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TN_cdi_doaj_primary_oai_doaj_org_article_7cf78e57b0794aac8b3b0de7021b5c2b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7cf78e57b0794aac8b3b0de7021b5c2b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19990-5
