Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
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Author / Creator
Chen, Xudong , Xie, Min , Zhang, Sensen , Monguió-Tortajada, Marta , Yin, Jian , Liu, Chang , Zhang, Youqi , Delacrétaz, Maeva , Song, Mingyue , Wang, Yixue , Dong, Lin , Ding, Qiang , Zhou, Boda , Tian, Xiaolin , Deng, Haiteng , Xu, Lina , Liu, Xiaohui , Yang, Zi , Chang, Qing , Na, Jie , Zeng, Wenwen , Superti-Furga, Giulio , Rebsamen, Manuele and Yang, Maojun
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Toll-like receptors (TLRs) are a class of proteins that play critical roles in recognizing pathogens and initiating innate immune responses. TASL, a recently identified innate immune adaptor protein for endolysosomal TLR7/8/9 signaling, is recruited by the lysosomal proton-coupled amino-acid transporter SLC15A4, and then activates IRF5, which in tu...
Alternative Titles
Full title
Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
Authors, Artists and Contributors
Author / Creator
Xie, Min
Zhang, Sensen
Monguió-Tortajada, Marta
Yin, Jian
Liu, Chang
Zhang, Youqi
Delacrétaz, Maeva
Song, Mingyue
Wang, Yixue
Dong, Lin
Ding, Qiang
Zhou, Boda
Tian, Xiaolin
Deng, Haiteng
Xu, Lina
Liu, Xiaohui
Yang, Zi
Chang, Qing
Na, Jie
Zeng, Wenwen
Superti-Furga, Giulio
Rebsamen, Manuele
Yang, Maojun
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7cfd7c5510254a58a60e7826c7afde97
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7cfd7c5510254a58a60e7826c7afde97
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42210-9
