Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1...
Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome
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Author / Creator
Hu, Penghui , Li, Huiyi , Ji, Zemin , Jing, Weijia , Li, Zihan , Yu, Sujun , Shan, Xiao , Cui, Yan , Wang, Baochen , Dong, Hongyuan , Zhou, Yanzhao , Wang, Zhe , Xiong, Hui , Zhang, Xiaomei , Li, Hui-chieh , Wang, Jinrong , Tang, Jiuzhou , Wang, Ting , Xie, Keliang , Liu, Yuping , Zhu, Haizhen and Yu, Qiujing
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Fructose-1,6-diphosphate (FBP), a key glycolytic metabolite, is recognized for its cytoprotective effects during stress. However, the role of FBP in viral infections is unknown. Here, we demonstrate that virus-infected cells exhibit elevated FBP levels. Exogenous FBP inhibits both RNA and DNA virus infections
in vitro
and
in vivo
. Modu...
Alternative Titles
Full title
Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7d3f2c448c2540268f4651da30de1736
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7d3f2c448c2540268f4651da30de1736
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1012782
