NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection aga...
NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent. We previously showed that the DNA-methylating drug temozolomide (TMZ) activates AKT, a positive modulator of NF-κB, in a mismatch repai...
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NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug
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TN_cdi_doaj_primary_oai_doaj_org_article_7d55a0d05d2e48328b90f654b0509e26
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7d55a0d05d2e48328b90f654b0509e26
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/1479-5876-10-252
