Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4/CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4/heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT). I...
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Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
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TN_cdi_doaj_primary_oai_doaj_org_article_7db93bca16bf4fa1820e09bfd6b94d15
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7db93bca16bf4fa1820e09bfd6b94d15
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14945
