Log in to save to my catalogue

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular ni...

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular ni...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7dde84bbf79f4a748ecf6d1fab0d7161

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

About this item

Full title

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2020-04, Vol.11 (1), p.2042-15, Article 2042

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The endothelial cell adhesion molecule E-selectin is a key component of the bone marrow hematopoietic stem cell (HSC) vascular niche regulating balance between HSC self-renewal and commitment. We now report in contrast, E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. Using acute myeloid leukemi...

Alternative Titles

Full title

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7dde84bbf79f4a748ecf6d1fab0d7161

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7dde84bbf79f4a748ecf6d1fab0d7161

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-020-15817-5

How to access this item