Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular ni...
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The endothelial cell adhesion molecule E-selectin is a key component of the bone marrow hematopoietic stem cell (HSC) vascular niche regulating balance between HSC self-renewal and commitment. We now report in contrast, E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. Using acute myeloid leukemi...
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Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
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TN_cdi_doaj_primary_oai_doaj_org_article_7dde84bbf79f4a748ecf6d1fab0d7161
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7dde84bbf79f4a748ecf6d1fab0d7161
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15817-5