Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resist...
Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Niclosamide has preclinical activity against a wide range of cancers. In prostate cancer, it inhibits androgen receptor variant 7 and synergizes with abiraterone. The approved niclosamide formulation has poor oral bioavailability. The primary objective of this phase Ib trial was to identify a maximum tolerated dose (MTD) and recommended phase 2 dos...
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Full title
Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_7deaebe005d14169a2841537a9f695b8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7deaebe005d14169a2841537a9f695b8
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-85969-x
