The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
About this item
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Author / Creator
Ottema, Sophie , Mulet-Lazaro, Roger , Erpelinck-Verschueren, Claudia , van Herk, Stanley , Havermans, Marije , Arricibita Varea, Andrea , Vermeulen, Michael , Beverloo, H. Berna , Gröschel, Stefan , Haferlach, Torsten , Haferlach, Claudia , J. Wouters, Bas , Bindels, Eric , Smeenk, Leonie and Delwel, Ruud
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of
EVI1
is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In AMLs harboring a t(3;8)(q26;q24), we observed the translocation of a
MYC
super-enhancer (...
Alternative Titles
Full title
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7df6196de175464e8b50bb614eba9c97
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7df6196de175464e8b50bb614eba9c97
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25862-3
